Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
magma_0_001 Exclusive	dgn	1.62e-02	1.53e-02	6.33e-05	2.46e-11
dgn Exclusive	magma_0_001	4.40e-02	8.72e-02	2.67e-05	2.74e-03
magma_0_001 Exclusive	dgn Exclusive	1.23e-01	2.18e-02	1.97e-04	2.48e-11
dgn Exclusive	magma_0_001 Exclusive	1.62e-01	2.38e-01	1.48e-03	4.46e-02
magma_0_001 Exclusive	Overlap	2.79e-02	4.84e-02	2.62e-02	2.09e-02
dgn Exclusive	Overlap	1.69e-04	4.61e-04	1.69e-04	1.86e-04
Overlap	Exclusives	2.14e-35	7.91e-49	4.27e-71	1.12e-67



Evaluating how well magma_0_001 genes are linked to dgn genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_001 Exclusive	dgn	0.67	1.11	2.25	1.22	8.20
dgn Exclusive	magma_0_001	0.67	4.77	3.01	2.83	3.74
magma_0_001 Exclusive	dgn Exclusive	0.67	0.68	1.75	1.11	7.91
dgn Exclusive	magma_0_001 Exclusive	0.62	3.99	1.82	1.78	2.58
magma_0_001 Exclusive	Overlap	0.84	2.39	1.78	1.67	2.66
dgn Exclusive	Overlap	1.00	4.88	2.94	2.95	3.79
Overlap	Exclusives	0.85	3.98	17.38	3.71	20.46

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_001 Exclusive	dgn	0.02	3.34	9.68	4.01	12.24
dgn Exclusive	magma_0_001	0.09	233.07	220.44	218.22	271.50
magma_0_001 Exclusive	dgn Exclusive	0.02	2.32	6.58	3.10	12.24
dgn Exclusive	magma_0_001 Exclusive	0.00	1.52	2.56	2.11	3.16
magma_0_001 Exclusive	Overlap	0.00	11.32	17.09	4.74	4.57
dgn Exclusive	Overlap	0.69	2137.09	680.91	1636.49	1279.35
Overlap	Exclusives	0.16	36.56	178.25	29.73	227.80

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
magma_0_001 Exclusive	27	27	
dgn Exclusive	204	202	PCDH11Y;SERPINA3
Overlap	4	4