Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
disc Exclusive	ctd	2.71e-03	1.21e-01	1.78e-22	3.61e-17
ctd Exclusive	disc	7.37e-05	5.03e-03	1.80e-17	3.48e-16
disc Exclusive	ctd Exclusive	6.10e-03	1.39e-01	1.86e-21	2.54e-16
ctd Exclusive	disc Exclusive	4.67e-05	1.37e-02	7.00e-17	6.87e-16
disc Exclusive	Overlap	3.94e-01	1.54e-01	1.28e-02	3.07e-02
ctd Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	3.04e-10	6.32e-13	1.55e-36	5.30e-42



Evaluating how well disc genes are linked to ctd genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc Exclusive	ctd	0.81	3.70	4.86	3.32	10.19
ctd Exclusive	disc	0.74	-4.94	3.48	2.41	11.57
disc Exclusive	ctd Exclusive	0.80	3.48	3.78	3.60	8.74
ctd Exclusive	disc Exclusive	0.73	-4.64	3.60	2.71	10.75
disc Exclusive	Overlap	0.92	2.20	1.21	1.87	2.03
ctd Exclusive	Overlap	1.00	2.90	2.64	2.54	2.34
Overlap	Exclusives	0.79	2.11	9.41	2.63	17.17

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc Exclusive	ctd	0.03	3.28	2.68	9.83	45.29
ctd Exclusive	disc	0.03	-0.72	7.70	11.89	22.07
disc Exclusive	ctd Exclusive	0.03	3.34	2.93	9.96	38.66
ctd Exclusive	disc Exclusive	0.03	-2.12	4.70	9.00	15.76
disc Exclusive	Overlap	0.00	0.29	0.94	2.29	0.10
ctd Exclusive	Overlap	0.13	855.40	641.35	745.86	627.13
Overlap	Exclusives	0.05	7.04	25.52	6.69	44.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
disc Exclusive	158	157	BRD2
ctd Exclusive	101	87	MIR3622B;MIR505;CTR1B;MIR146A;MIR766;MIR100;MIR375;ATP7;CTR1C;SNAR-I;MIR124A-3;MIR296;MIR708;MIR4467
Overlap	2	2