Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
disc	clinvar	2.63e-03	4.60e-03	3.63e-10	2.47e-08
clinvar	disc	3.54e-05	6.33e-05	2.24e-11	5.28e-18



Evaluating how well disc genes are linked to clinvar genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc	clinvar	0.84	5.66	5.37	4.25	5.36
clinvar	disc	0.74	0.22	5.48	1.04	10.81

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc	clinvar	0.01	4.53	11.72	8.26	10.82
clinvar	disc	0.02	3.50	7.88	5.52	16.39

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
disc	160	159	BRD2
clinvar	21	21