Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
magma_0_01 Exclusive	ctd	4.55e-02	6.66e-03	2.68e-02	2.01e-13
ctd Exclusive	magma_0_01	7.05e-03	7.68e-02	2.53e-08	3.31e-02
magma_0_01 Exclusive	ctd Exclusive	1.60e-02	5.06e-03	7.98e-03	1.03e-13
ctd Exclusive	magma_0_01 Exclusive	3.46e-02	2.01e-01	3.26e-07	1.59e-01
magma_0_01 Exclusive	Overlap	4.99e-01	5.68e-01	5.84e-01	8.47e-01
ctd Exclusive	Overlap	2.19e-05	1.70e-04	2.52e-05	4.51e-05
Overlap	Exclusives	5.11e-06	3.72e-06	2.11e-25	9.65e-13



Evaluating how well magma_0_01 genes are linked to ctd genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_01 Exclusive	ctd	0.74	1.69	3.10	1.34	7.45
ctd Exclusive	magma_0_01	0.53	1.57	0.41	0.64	1.61
magma_0_01 Exclusive	ctd Exclusive	0.75	1.96	3.18	1.79	7.85
ctd Exclusive	magma_0_01 Exclusive	0.52	1.09	0.03	0.47	0.88
magma_0_01 Exclusive	Overlap	0.60	-1.12	-0.58	-0.81	0.58
ctd Exclusive	Overlap	0.99	5.58	3.44	3.86	3.91
Overlap	Exclusives	0.62	3.92	4.92	3.39	7.35

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_01 Exclusive	ctd	0.01	1.27	6.21	1.17	7.19
ctd Exclusive	magma_0_01	0.02	8.80	6.32	4.56	6.10
magma_0_01 Exclusive	ctd Exclusive	0.01	1.49	5.70	1.38	6.10
ctd Exclusive	magma_0_01 Exclusive	0.01	2.46	1.63	1.44	1.38
magma_0_01 Exclusive	Overlap	0.00	-0.25	0.25	-0.09	0.23
ctd Exclusive	Overlap	0.08	203.07	170.46	96.14	264.46
Overlap	Exclusives	0.04	10.50	20.13	11.36	18.94

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
magma_0_01 Exclusive	229	217	PSORS1C1;KIAA1751;FAM154B;RTFDC1;C17orf107;C1orf228;C2orf43;MICA;CCDC168;IGH;C2CD5;PRR27
ctd Exclusive	98	84	MIR708;MIR124A-3;MIR3622B;MIR375;MIR4467;MIR100;MIR296;CTR1C;MIR766;MIR505;ATP7;SNAR-I;MIR146A;CTR1B
Overlap	5	5