Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
magma_0_01 Exclusive	gwas	9.73e-01	8.83e-01	9.86e-01	3.18e-01
gwas Exclusive	magma_0_01	5.76e-03	1.59e-01	6.79e-02	8.36e-01
magma_0_01 Exclusive	gwas Exclusive	9.12e-01	7.24e-01	9.53e-01	2.81e-01
gwas Exclusive	magma_0_01 Exclusive	3.82e-03	1.05e-01	1.16e-01	7.67e-01
magma_0_01 Exclusive	Overlap	5.53e-01	8.14e-01	8.41e-01	8.67e-01
gwas Exclusive	Overlap	1.53e-03	1.68e-03	1.45e-03	1.76e-03
Overlap	Exclusives	9.41e-02	9.39e-02	1.41e-13	2.31e-02



Evaluating how well magma_0_01 genes are linked to gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_01 Exclusive	gwas	0.58	-0.15	0.08	-0.28	1.60
gwas Exclusive	magma_0_01	0.50	-1.56	-1.47	-1.01	0.14
magma_0_01 Exclusive	gwas Exclusive	0.59	0.23	0.51	0.03	1.31
gwas Exclusive	magma_0_01 Exclusive	0.49	-1.85	-1.98	-1.56	-0.22
magma_0_01 Exclusive	Overlap	0.54	-1.05	-0.94	-0.67	0.27
gwas Exclusive	Overlap	0.99	2.88	3.39	3.46	2.71
Overlap	Exclusives	0.55	2.64	1.36	1.99	2.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_01 Exclusive	gwas	0.00	-0.34	-0.34	-0.46	0.05
gwas Exclusive	magma_0_01	0.01	0.74	1.11	0.34	1.08
magma_0_01 Exclusive	gwas Exclusive	0.00	-0.29	-0.27	-0.24	0.13
gwas Exclusive	magma_0_01 Exclusive	0.01	-0.68	-0.54	-0.74	0.03
magma_0_01 Exclusive	Overlap	0.00	0.19	1.31	0.89	0.24
gwas Exclusive	Overlap	0.03	35.98	75.90	101.05	23.59
Overlap	Exclusives	0.02	4.42	3.09	4.55	3.44

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
magma_0_01 Exclusive	231	219	PSORS1C1;C2orf43;IGH;FAM154B;CCDC168;C17orf107;C1orf228;C2CD5;MICA;KIAA1751;RTFDC1;PRR27
gwas Exclusive	22	21	HLA -DRB1
Overlap	3	3