Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
magma_0_01 Exclusive	clinvar	1.58e-01	1.48e-02	1.47e-01	5.46e-03
clinvar Exclusive	magma_0_01	2.54e-01	5.02e-01	2.20e-05	5.96e-01
magma_0_01 Exclusive	clinvar Exclusive	3.67e-01	2.38e-02	1.72e-01	1.63e-02
clinvar Exclusive	magma_0_01 Exclusive	2.05e-01	6.16e-01	3.11e-05	7.29e-01
magma_0_01 Exclusive	Overlap	9.92e-02	9.92e-02	1.18e-01	9.92e-02
clinvar Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.05e-01
Overlap	Exclusives	6.56e-05	4.82e-02	8.68e-55	5.19e-03



Evaluating how well magma_0_01 genes are linked to clinvar genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_01 Exclusive	clinvar	0.69	0.62	1.23	0.58	2.72
clinvar Exclusive	magma_0_01	0.52	1.57	-0.11	0.26	1.09
magma_0_01 Exclusive	clinvar Exclusive	0.67	0.35	1.28	0.68	2.99
clinvar Exclusive	magma_0_01 Exclusive	0.52	1.18	-0.07	0.24	0.95
magma_0_01 Exclusive	Overlap	0.99	1.18	2.09	1.02	1.64
clinvar Exclusive	Overlap	1.00	1.65	1.74	1.63	1.85
Overlap	Exclusives	0.55	3.86	1.99	1.98	3.21

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_01 Exclusive	clinvar	0.00	1.42	6.04	1.52	3.67
clinvar Exclusive	magma_0_01	0.01	1.08	1.33	0.40	1.41
magma_0_01 Exclusive	clinvar Exclusive	0.00	0.41	5.08	1.35	5.01
clinvar Exclusive	magma_0_01 Exclusive	0.01	0.80	0.55	0.43	0.65
magma_0_01 Exclusive	Overlap	0.00	6.18	10.92	2.43	19.88
clinvar Exclusive	Overlap	0.01	32.25	68.05	35.45	7.06
Overlap	Exclusives	0.02	13.46	9.08	5.53	6.74

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
magma_0_01 Exclusive	233	221	MICA;PRR27;KIAA1751;C2CD5;C17orf107;IGH;CCDC168;RTFDC1;PSORS1C1;C2orf43;C1orf228;FAM154B
clinvar Exclusive	20	20	
Overlap	1	1