Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
magma_0_001 Exclusive	ctd	5.69e-05	6.94e-08	6.60e-08	7.16e-20
ctd Exclusive	magma_0_001	2.72e-02	1.46e-02	2.54e-05	1.81e-03
magma_0_001 Exclusive	ctd Exclusive	5.37e-04	2.87e-07	2.77e-07	3.57e-19
ctd Exclusive	magma_0_001 Exclusive	1.29e-01	5.34e-02	9.08e-04	1.82e-02
magma_0_001 Exclusive	Overlap	3.39e-01	1.54e-01	3.39e-01	2.27e-01
ctd Exclusive	Overlap	1.38e-03	1.09e-02	1.45e-03	2.23e-03
Overlap	Exclusives	1.63e-17	8.86e-20	1.26e-33	5.41e-34



Evaluating how well magma_0_001 genes are linked to ctd genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_001 Exclusive	ctd	0.79	3.22	6.62	2.77	10.34
ctd Exclusive	magma_0_001	0.68	4.03	2.56	2.89	3.01
magma_0_001 Exclusive	ctd Exclusive	0.79	2.91	6.24	2.48	9.11
ctd Exclusive	magma_0_001 Exclusive	0.64	2.76	2.50	1.82	2.77
magma_0_001 Exclusive	Overlap	0.73	0.45	1.42	0.89	1.24
ctd Exclusive	Overlap	0.98	5.91	2.73	2.94	2.81
Overlap	Exclusives	0.85	4.38	10.51	3.78	12.05

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_001 Exclusive	ctd	0.01	3.48	9.24	3.60	13.07
ctd Exclusive	magma_0_001	0.02	32.05	37.32	24.15	34.93
magma_0_001 Exclusive	ctd Exclusive	0.01	2.99	7.78	2.78	5.43
ctd Exclusive	magma_0_001 Exclusive	0.01	6.51	13.41	5.39	10.22
magma_0_001 Exclusive	Overlap	0.00	0.15	6.29	3.47	0.05
ctd Exclusive	Overlap	0.04	135.23	89.53	70.80	72.83
Overlap	Exclusives	0.04	9.37	37.40	9.32	24.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
magma_0_001 Exclusive	28	26	KIAA1751;MICA
ctd Exclusive	100	86	ATP7;SNAR-I;MIR296;CTR1C;MIR708;MIR124A-3;CTR1B;MIR766;MIR3622B;MIR4467;MIR375;MIR146A;MIR505;MIR100
Overlap	3	3