Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
magma_0_001 Exclusive	gwas	9.35e-01	3.13e-01	2.43e-01	2.10e-02
gwas Exclusive	magma_0_001	2.30e-01	2.63e-01	6.85e-02	5.49e-02
magma_0_001 Exclusive	gwas Exclusive	7.57e-01	2.78e-01	2.20e-01	1.35e-02
gwas Exclusive	magma_0_001 Exclusive	5.80e-01	7.44e-01	1.57e-01	2.63e-01
magma_0_001 Exclusive	Overlap	8.59e-01	6.59e-01	8.41e-01	5.12e-01
gwas Exclusive	Overlap	1.53e-03	1.68e-03	1.45e-03	1.60e-03
Overlap	Exclusives	2.74e-06	3.44e-05	5.11e-11	2.35e-07



Evaluating how well magma_0_001 genes are linked to gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_001 Exclusive	gwas	0.66	0.68	1.63	0.74	2.59
gwas Exclusive	magma_0_001	0.63	2.49	2.13	2.15	2.92
magma_0_001 Exclusive	gwas Exclusive	0.65	1.06	1.97	1.07	2.23
gwas Exclusive	magma_0_001 Exclusive	0.59	1.65	1.20	1.14	2.01
magma_0_001 Exclusive	Overlap	0.66	-0.07	0.43	0.33	1.00
gwas Exclusive	Overlap	0.99	2.79	3.32	3.02	3.27
Overlap	Exclusives	0.75	6.67	5.70	3.93	6.20

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_001 Exclusive	gwas	0.00	0.05	1.15	0.02	0.81
gwas Exclusive	magma_0_001	0.01	5.16	8.35	7.67	10.29
magma_0_001 Exclusive	gwas Exclusive	0.00	0.07	0.53	-0.05	0.23
gwas Exclusive	magma_0_001 Exclusive	0.00	0.25	0.12	0.13	0.58
magma_0_001 Exclusive	Overlap	0.00	-0.07	2.99	1.56	1.80
gwas Exclusive	Overlap	0.03	22.21	11.29	72.93	36.42
Overlap	Exclusives	0.02	10.09	20.50	17.03	25.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
magma_0_001 Exclusive	28	26	MICA;KIAA1751
gwas Exclusive	22	21	HLA -DRB1
Overlap	3	3