Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
magma_0_001 Exclusive	dgn	9.10e-02	2.10e-01	1.77e-02	2.45e-16
dgn Exclusive	magma_0_001	9.23e-02	4.42e-02	1.36e-03	2.68e-03
magma_0_001 Exclusive	dgn Exclusive	1.54e-01	1.73e-01	3.21e-02	1.05e-15
dgn Exclusive	magma_0_001 Exclusive	2.50e-01	1.78e-01	2.33e-02	2.22e-02
magma_0_001 Exclusive	Overlap	9.58e-01	9.46e-01	9.65e-01	6.50e-01
dgn Exclusive	Overlap	1.69e-04	1.95e-04	1.69e-04	2.24e-04
Overlap	Exclusives	2.43e-40	2.65e-43	1.10e-63	9.11e-59



Evaluating how well magma_0_001 genes are linked to dgn genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_001 Exclusive	dgn	0.65	-0.27	2.16	0.45	7.67
dgn Exclusive	magma_0_001	0.66	4.12	2.84	2.82	2.84
magma_0_001 Exclusive	dgn Exclusive	0.65	-0.05	2.22	0.39	7.56
dgn Exclusive	magma_0_001 Exclusive	0.61	2.59	1.50	1.57	1.88
magma_0_001 Exclusive	Overlap	0.63	-0.34	-0.22	-0.06	0.93
dgn Exclusive	Overlap	0.99	5.61	3.44	3.55	3.18
Overlap	Exclusives	0.84	4.78	19.52	4.33	17.52

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_001 Exclusive	dgn	0.02	0.21	2.99	0.86	6.40
dgn Exclusive	magma_0_001	0.03	84.40	74.49	7.35	38.62
magma_0_001 Exclusive	dgn Exclusive	0.02	0.52	2.83	0.82	6.24
dgn Exclusive	magma_0_001 Exclusive	0.00	1.20	0.73	-0.08	0.63
magma_0_001 Exclusive	Overlap	0.00	0.34	0.47	0.15	-0.07
dgn Exclusive	Overlap	0.18	865.52	452.51	412.09	192.93
Overlap	Exclusives	0.09	20.83	85.89	19.46	83.59

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
magma_0_001 Exclusive	27	25	MICA;KIAA1751
dgn Exclusive	204	202	C10orf105;MCIDAS
Overlap	4	4