Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ext Exclusive	dgn	6.80e-03	4.04e-01	1.17e-34	7.24e-17
dgn Exclusive	ext	3.08e-04	1.24e-02	8.20e-16	3.37e-23
ext Exclusive	dgn Exclusive	3.89e-02	3.57e-01	5.00e-31	2.40e-14
dgn Exclusive	ext Exclusive	1.22e-04	1.96e-02	2.50e-11	4.46e-21
ext Exclusive	Overlap	2.62e-02	7.97e-01	2.30e-08	6.23e-06
dgn Exclusive	Overlap	1.90e-10	2.16e-07	9.13e-11	5.91e-10
Overlap	Exclusives	4.74e-18	2.96e-28	1.19e-64	1.68e-69



Evaluating how well ext genes are linked to dgn genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ext Exclusive	dgn	0.68	2.07	1.30	2.56	8.44
dgn Exclusive	ext	0.77	-3.58	4.35	1.65	10.86
ext Exclusive	dgn Exclusive	0.67	1.58	1.34	2.61	8.17
dgn Exclusive	ext Exclusive	0.75	-4.80	2.83	1.06	10.86
ext Exclusive	Overlap	0.90	3.66	0.51	2.16	4.68
dgn Exclusive	Overlap	0.99	3.40	5.98	3.98	5.64
Overlap	Exclusives	0.81	8.16	14.50	4.71	19.96

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ext Exclusive	dgn	0.02	1.82	0.23	4.01	9.54
dgn Exclusive	ext	0.03	-0.75	11.96	7.29	36.83
ext Exclusive	dgn Exclusive	0.02	1.05	0.84	3.95	8.43
dgn Exclusive	ext Exclusive	0.02	-3.73	2.00	1.83	12.46
ext Exclusive	Overlap	0.00	6.10	-0.74	3.88	4.20
dgn Exclusive	Overlap	0.10	75.67	173.87	180.33	329.09
Overlap	Exclusives	0.09	16.55	49.17	20.13	79.94

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ext Exclusive	144	143	BRD2
dgn Exclusive	197	195	C10orf105;MCIDAS
Overlap	11	11