Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hint pp	clinvar	2.09e-03	2.38e-04	9.13e-06	6.21e-07
clinvar	hint pp	1.43e-02	2.38e-02	2.92e-06	2.13e-05



Evaluating how well hint pp genes are linked to clinvar genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hint pp	clinvar	0.80	2.90	3.84	2.68	4.53
clinvar	hint pp	0.65	2.69	3.30	2.72	5.61

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hint pp	clinvar	0.01	2.12	9.47	8.02	4.58
clinvar	hint pp	0.01	3.47	4.70	5.20	7.93

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hint pp	103	103	
clinvar	21	21