Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	GS	2.13e-03	1.86e-04	1.52e-01	8.85e-17
GS Exclusive	gene_list	2.68e-01	5.13e-02	1.91e-02	1.03e-01
gene_list Exclusive	GS Exclusive	7.84e-03	4.20e-04	3.34e-01	1.74e-16
GS Exclusive	gene_list Exclusive	2.01e-01	8.26e-02	6.04e-02	1.45e-01
gene_list Exclusive	Overlap	4.35e-01	2.78e-01	7.54e-01	2.78e-01
GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	6.05e-19	2.03e-20	3.55e-24	1.35e-26



Evaluating how well gene_list genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.81	1.34	4.52	1.37	7.92
GS Exclusive	gene_list	0.68	3.66	2.38	2.20	1.71
gene_list Exclusive	GS Exclusive	0.81	1.30	4.53	1.46	7.32
GS Exclusive	gene_list Exclusive	0.62	3.11	1.87	1.31	1.22
gene_list Exclusive	Overlap	0.83	0.53	1.08	0.73	1.10
GS Exclusive	Overlap	1.00	2.43	1.67	1.73	1.95
Overlap	Exclusives	0.89	1.92	8.54	2.41	12.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.01	1.23	5.34	1.22	8.27
GS Exclusive	gene_list	0.01	49.71	22.88	21.21	3.21
gene_list Exclusive	GS Exclusive	0.01	1.00	5.58	1.27	7.63
GS Exclusive	gene_list Exclusive	0.00	4.19	0.30	-0.03	-0.01
gene_list Exclusive	Overlap	0.00	-0.22	-0.20	-0.12	-0.02
GS Exclusive	Overlap	0.05	689.30	188.12	86.33	173.80
Overlap	Exclusives	0.03	6.18	47.33	8.52	63.66

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	6	6	
GS Exclusive	54	54	
Overlap	1	1