Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000_to_2500	GS	5.55e-05	2.37e-05	1.61e-04	4.52e-07
GS	1000_to_2500	6.68e-01	7.53e-01	3.18e-02	3.23e-01



Evaluating how well 1000_to_2500 genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000_to_2500	GS	0.88	3.13	5.34	2.43	5.25
GS	1000_to_2500	0.49	1.31	0.36	0.47	-0.28

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000_to_2500	GS	0.00	4.49	18.67	2.05	2.04
GS	1000_to_2500	0.00	4.14	5.19	5.34	3.83

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000_to_2500	18	18	
GS	14	14