Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	GS	9.43e-01	9.45e-01	4.28e-01	5.53e-02
GS Exclusive	gene_list	3.33e-09	1.13e-01	8.60e-20	1.41e-01
gene_list Exclusive	GS Exclusive	5.48e-01	8.68e-01	3.38e-01	5.80e-02
GS Exclusive	gene_list Exclusive	4.74e-09	1.03e-01	1.59e-20	1.47e-01
gene_list Exclusive	Overlap	3.51e-01	4.35e-01	4.00e-01	3.35e-01
GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	1.09e-01	3.71e-01	1.39e-14	1.93e-01



Evaluating how well gene_list genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.68	-0.32	-0.22	-0.86	2.33
GS Exclusive	gene_list	0.50	-0.25	-0.02	0.28	0.15
gene_list Exclusive	GS Exclusive	0.67	-0.63	-0.75	-0.89	2.60
GS Exclusive	gene_list Exclusive	0.50	-0.17	-0.08	0.32	0.19
gene_list Exclusive	Overlap	0.75	0.80	0.83	0.76	0.89
GS Exclusive	Overlap	1.00	2.62	1.97	2.23	1.60
Overlap	Exclusives	0.52	0.51	1.52	0.42	1.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.00	-0.65	-0.86	-0.97	0.51
GS Exclusive	gene_list	0.03	-0.45	-0.23	-0.11	-0.59
gene_list Exclusive	GS Exclusive	0.00	-0.79	-1.05	-0.92	1.19
GS Exclusive	gene_list Exclusive	0.03	-0.55	-0.33	-0.33	-0.64
gene_list Exclusive	Overlap	0.00	0.24	-0.10	0.16	-0.13
GS Exclusive	Overlap	0.02	247.28	85.36	61.14	12.13
Overlap	Exclusives	0.03	1.13	4.03	1.24	3.26

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	550	549	UGT2A1
GS Exclusive	19	19	
Overlap	1	1