Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	GS	8.53e-03	9.40e-04	2.83e-01	5.24e-08
GS Exclusive	gene_list	5.08e-01	4.18e-01	7.05e-02	4.89e-01
gene_list Exclusive	GS Exclusive	1.35e-02	1.76e-03	1.95e-01	1.17e-07
GS Exclusive	gene_list Exclusive	3.90e-01	2.82e-01	5.25e-02	6.85e-01
gene_list Exclusive	Overlap	4.17e-01	2.78e-01	6.11e-01	2.40e-01
GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.05e-01
Overlap	Exclusives	2.15e-11	1.16e-10	1.86e-11	2.88e-11



Evaluating how well gene_list genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.81	1.36	3.44	1.36	4.49
GS Exclusive	gene_list	0.61	2.58	1.70	1.74	1.28
gene_list Exclusive	GS Exclusive	0.81	1.76	3.09	1.55	4.42
GS Exclusive	gene_list Exclusive	0.55	1.86	1.29	1.31	0.30
gene_list Exclusive	Overlap	0.83	0.58	1.10	0.62	1.26
GS Exclusive	Overlap	1.00	1.51	2.08	1.94	1.78
Overlap	Exclusives	0.86	2.44	5.64	2.69	6.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.00	0.73	2.10	0.12	0.90
GS Exclusive	gene_list	0.01	10.35	35.83	4.35	2.68
gene_list Exclusive	GS Exclusive	0.00	1.11	2.56	0.74	0.80
GS Exclusive	gene_list Exclusive	0.00	-0.08	-0.10	-0.21	-0.24
gene_list Exclusive	Overlap	0.00	-0.17	-0.11	-0.14	0.13
GS Exclusive	Overlap	0.04	11.58	207.07	147.27	6.94
Overlap	Exclusives	0.03	13.24	46.31	26.72	65.56

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	6	6	
GS Exclusive	19	19	
Overlap	1	1