Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GroupA	GroupB	7.14e-01	4.49e-01	9.31e-01	1.71e-02
GroupB	GroupA	9.44e-01	7.21e-01	1.11e-01	9.89e-01



Evaluating how well GroupA genes are linked to GroupB genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GroupA	GroupB	0.83	0.13	1.15	0.19	2.51
GroupB	GroupA	0.50	0.10	-0.64	-0.37	0.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GroupA	GroupB	0.00	0.09	0.87	0.11	0.92
GroupB	GroupA	0.00	0.14	-0.38	-0.23	-0.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GroupA	5	5	
GroupB	4	4