Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
disc Exclusive	ctd	1.45e-04	1.90e-02	1.34e-22	8.40e-18
ctd Exclusive	disc	8.88e-06	2.14e-03	1.25e-17	7.19e-15
disc Exclusive	ctd Exclusive	3.91e-04	1.94e-02	6.66e-22	2.78e-16
ctd Exclusive	disc Exclusive	5.75e-06	4.58e-03	7.35e-17	1.48e-14
disc Exclusive	Overlap	3.94e-01	4.17e-01	1.28e-02	6.25e-02
ctd Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	5.08e-09	4.57e-13	1.50e-36	8.47e-41



Evaluating how well disc genes are linked to ctd genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc Exclusive	ctd	0.81	4.09	4.16	3.51	8.54
ctd Exclusive	disc	0.73	-4.14	3.81	2.47	10.22
disc Exclusive	ctd Exclusive	0.81	3.86	4.18	3.65	10.16
ctd Exclusive	disc Exclusive	0.72	-4.72	3.56	2.21	10.23
disc Exclusive	Overlap	0.91	1.90	1.06	1.92	1.83
ctd Exclusive	Overlap	1.00	2.90	2.29	2.50	2.22
Overlap	Exclusives	0.79	1.91	9.00	2.32	16.14

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc Exclusive	ctd	0.03	4.07	3.44	10.65	17.05
ctd Exclusive	disc	0.03	-0.27	11.39	12.67	30.22
disc Exclusive	ctd Exclusive	0.03	3.72	3.32	9.48	45.62
ctd Exclusive	disc Exclusive	0.03	-1.72	6.77	8.98	23.32
disc Exclusive	Overlap	0.00	0.54	0.70	2.74	0.24
ctd Exclusive	Overlap	0.13	595.40	510.02	522.09	219.18
Overlap	Exclusives	0.05	5.87	22.50	5.67	37.27

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
disc Exclusive	157	156	BRD2
ctd Exclusive	101	87	MIR124A-3;ATP7;MIR766;SNAR-I;MIR505;MIR3622B;CTR1B;MIR4467;MIR146A;MIR296;CTR1C;MIR375;MIR100;MIR708
Overlap	2	2