Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
disc	clinvar	2.27e-03	9.95e-03	2.67e-09	7.00e-08
clinvar	disc	3.40e-05	1.94e-05	5.67e-12	2.46e-17



Evaluating how well disc genes are linked to clinvar genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc	clinvar	0.83	4.41	4.60	3.07	4.47
clinvar	disc	0.73	0.01	4.79	1.06	11.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc	clinvar	0.01	6.30	9.60	9.73	21.90
clinvar	disc	0.02	3.45	8.82	5.67	14.32

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
disc	159	158	BRD2
clinvar	21	21