Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ext Exclusive	ctd	5.32e-03	3.45e-01	6.23e-24	1.12e-15
ctd Exclusive	ext	7.92e-05	3.31e-03	3.26e-23	1.82e-20
ext Exclusive	ctd Exclusive	1.37e-02	3.63e-01	5.92e-21	5.45e-14
ctd Exclusive	ext Exclusive	3.38e-05	1.03e-02	5.38e-21	3.88e-18
ext Exclusive	Overlap	3.31e-02	8.72e-01	2.75e-05	4.49e-04
ctd Exclusive	Overlap	2.19e-05	1.70e-04	2.10e-05	3.61e-05
Overlap	Exclusives	4.31e-10	3.52e-14	5.78e-62	9.88e-54



Evaluating how well ext genes are linked to ctd genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ext Exclusive	ctd	0.78	4.00	2.39	3.27	7.39
ctd Exclusive	ext	0.75	-5.03	3.82	1.67	10.91
ext Exclusive	ctd Exclusive	0.77	3.64	2.45	3.09	8.61
ctd Exclusive	ext Exclusive	0.74	-6.37	3.29	1.39	9.40
ext Exclusive	Overlap	0.96	4.46	1.15	2.19	3.69
ctd Exclusive	Overlap	0.99	2.04	4.94	3.06	3.66
Overlap	Exclusives	0.81	6.95	10.78	2.73	19.14

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ext Exclusive	ctd	0.02	4.80	0.02	6.76	11.17
ctd Exclusive	ext	0.03	-0.24	14.07	12.57	37.48
ext Exclusive	ctd Exclusive	0.02	4.30	-0.16	7.58	22.95
ctd Exclusive	ext Exclusive	0.02	-3.08	4.94	4.96	20.69
ext Exclusive	Overlap	0.00	10.44	-0.58	7.48	0.10
ctd Exclusive	Overlap	0.15	128.50	402.02	439.22	383.50
Overlap	Exclusives	0.07	19.13	55.67	13.27	84.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ext Exclusive	153	152	BRD2
ctd Exclusive	98	84	MIR4467;MIR766;MIR3622B;MIR708;MIR375;ATP7;MIR146A;CTR1C;CTR1B;SNAR-I;MIR124A-3;MIR505;MIR100;MIR296
Overlap	5	5