Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ext Exclusive	dgn	2.37e-02	3.27e-01	2.76e-36	2.12e-17
dgn Exclusive	ext	1.27e-03	1.95e-02	4.33e-16	2.23e-23
ext Exclusive	dgn Exclusive	5.39e-02	4.43e-01	3.32e-31	8.85e-15
dgn Exclusive	ext Exclusive	5.59e-04	3.73e-02	1.22e-11	1.40e-21
ext Exclusive	Overlap	7.39e-03	4.59e-01	1.15e-08	1.82e-06
dgn Exclusive	Overlap	1.74e-10	2.02e-07	8.74e-11	7.28e-10
Overlap	Exclusives	1.44e-18	4.00e-28	4.65e-67	1.99e-68



Evaluating how well ext genes are linked to dgn genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ext Exclusive	dgn	0.68	2.15	1.41	2.59	9.77
dgn Exclusive	ext	0.77	-3.38	3.86	1.74	11.79
ext Exclusive	dgn Exclusive	0.67	1.45	1.23	2.22	8.21
dgn Exclusive	ext Exclusive	0.75	-4.51	2.83	0.84	10.96
ext Exclusive	Overlap	0.92	3.94	1.00	2.73	5.26
dgn Exclusive	Overlap	0.99	3.33	5.32	3.73	5.31
Overlap	Exclusives	0.81	7.14	14.49	4.26	20.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ext Exclusive	dgn	0.02	1.69	0.59	3.94	12.00
dgn Exclusive	ext	0.04	-1.02	9.98	6.53	36.25
ext Exclusive	dgn Exclusive	0.02	0.99	0.91	3.34	9.44
dgn Exclusive	ext Exclusive	0.02	-3.90	1.91	1.58	13.58
ext Exclusive	Overlap	0.00	6.09	-0.69	4.49	6.15
dgn Exclusive	Overlap	0.10	104.48	176.30	170.14	166.02
Overlap	Exclusives	0.10	15.32	49.73	17.38	79.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ext Exclusive	147	146	BRD2
dgn Exclusive	197	195	MCIDAS;C10orf105
Overlap	11	11