Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	GS	9.63e-03	5.96e-04	1.64e-01	4.58e-08
GS Exclusive	gene_list	4.89e-01	3.63e-01	8.81e-02	6.00e-01
gene_list Exclusive	GS Exclusive	9.10e-03	1.55e-03	1.82e-01	1.67e-07
GS Exclusive	gene_list Exclusive	3.55e-01	2.54e-01	6.77e-02	6.63e-01
gene_list Exclusive	Overlap	4.00e-01	3.06e-01	5.50e-01	2.40e-01
GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	2.09e-11	6.62e-11	1.35e-11	2.49e-11



Evaluating how well gene_list genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.81	1.41	4.13	1.55	5.33
GS Exclusive	gene_list	0.61	2.36	1.65	1.52	0.99
gene_list Exclusive	GS Exclusive	0.81	1.41	3.62	1.59	4.33
GS Exclusive	gene_list Exclusive	0.55	1.81	1.29	1.04	0.34
gene_list Exclusive	Overlap	0.83	0.55	1.01	0.80	1.13
GS Exclusive	Overlap	1.00	1.55	1.77	1.81	1.84
Overlap	Exclusives	0.86	2.27	5.90	2.65	6.55

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.00	0.90	4.22	0.45	3.02
GS Exclusive	gene_list	0.01	1.57	35.25	6.86	14.77
gene_list Exclusive	GS Exclusive	0.00	0.87	2.67	0.58	3.43
GS Exclusive	gene_list Exclusive	0.00	-0.11	-0.00	-0.23	-0.42
gene_list Exclusive	Overlap	0.00	-0.25	-0.16	-0.10	0.21
GS Exclusive	Overlap	0.04	37.70	230.37	50.70	45.35
Overlap	Exclusives	0.03	15.07	45.53	15.14	61.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	6	6	
GS Exclusive	19	19	
Overlap	1	1