Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	GS	5.30e-01	4.62e-01	7.05e-02	2.99e-01
GS Exclusive	gene_list	3.62e-04	5.27e-01	1.42e-05	3.81e-02
gene_list Exclusive	GS Exclusive	5.59e-01	4.70e-01	1.08e-01	3.29e-01
GS Exclusive	gene_list Exclusive	7.93e-05	3.56e-01	1.72e-06	2.74e-02
gene_list Exclusive	Overlap	6.74e-01	6.87e-01	2.84e-01	6.47e-01
GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	1.70e-05	1.54e-01	9.08e-14	1.47e-01



Evaluating how well gene_list genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.58	-0.76	-1.12	-1.26	1.34
GS Exclusive	gene_list	0.47	-0.58	-0.69	-1.06	-1.67
gene_list Exclusive	GS Exclusive	0.58	-0.80	-1.55	-1.38	1.57
GS Exclusive	gene_list Exclusive	0.46	-1.06	-0.94	-1.16	-1.78
gene_list Exclusive	Overlap	0.57	-0.09	0.23	-0.32	0.25
GS Exclusive	Overlap	1.00	3.22	2.77	2.63	2.33
Overlap	Exclusives	0.52	1.18	1.65	0.95	0.97

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.00	-0.88	-1.28	-0.96	-0.14
GS Exclusive	gene_list	0.01	1.08	1.04	0.52	-0.03
gene_list Exclusive	GS Exclusive	0.00	-0.79	-1.43	-1.05	0.12
GS Exclusive	gene_list Exclusive	0.01	-0.69	-1.01	-1.08	-1.82
gene_list Exclusive	Overlap	0.00	-0.41	-0.33	-0.24	-0.22
GS Exclusive	Overlap	0.10	29.31	64.35	400.00	283.07
Overlap	Exclusives	0.02	11.98	19.40	9.77	12.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	194	192	PRAG1;PCDH11Y
GS Exclusive	18	18	
Overlap	2	2