Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
disc	gwas	3.11e-01	4.81e-02	4.22e-04	3.84e-03
gwas	disc	3.29e-01	6.51e-01	1.46e-01	1.77e-03



Evaluating how well disc genes are linked to gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc	gwas	0.69	-0.55	2.19	1.26	3.05
gwas	disc	0.72	0.79	1.18	0.95	3.43

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc	gwas	0.00	-0.31	1.06	0.38	4.48
gwas	disc	0.00	1.32	0.26	2.28	5.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
disc	24	24	
gwas	25	24	HLA -DRB1