Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
disc Exclusive	ctd	2.45e-03	1.74e-02	2.45e-22	1.01e-16
ctd Exclusive	disc	5.66e-05	9.23e-03	1.10e-17	1.70e-16
disc Exclusive	ctd Exclusive	2.64e-03	2.88e-02	5.36e-21	9.17e-16
ctd Exclusive	disc Exclusive	6.26e-05	1.41e-02	7.40e-17	2.45e-16
disc Exclusive	Overlap	5.66e-01	6.33e-01	1.35e-02	4.23e-02
ctd Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	7.91e-10	8.09e-12	2.26e-35	1.20e-40



Evaluating how well disc genes are linked to ctd genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc Exclusive	ctd	0.81	3.30	4.55	3.82	11.21
ctd Exclusive	disc	0.73	-4.33	3.71	1.98	9.69
disc Exclusive	ctd Exclusive	0.81	3.68	4.29	3.57	9.09
ctd Exclusive	disc Exclusive	0.73	-4.13	3.42	2.06	9.57
disc Exclusive	Overlap	0.90	1.87	1.01	1.96	1.96
ctd Exclusive	Overlap	1.00	2.59	2.71	3.13	2.40
Overlap	Exclusives	0.79	2.26	9.04	2.43	15.85

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc Exclusive	ctd	0.03	2.39	3.08	9.90	41.29
ctd Exclusive	disc	0.03	-0.77	8.68	9.89	29.00
disc Exclusive	ctd Exclusive	0.03	2.32	3.31	9.45	17.04
ctd Exclusive	disc Exclusive	0.02	-1.91	4.74	7.31	16.52
disc Exclusive	Overlap	0.00	0.35	0.40	2.02	1.28
ctd Exclusive	Overlap	0.13	409.13	732.78	987.09	270.26
Overlap	Exclusives	0.05	7.31	23.34	5.42	47.57

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
disc Exclusive	156	155	BRD2
ctd Exclusive	101	87	CTR1C;SNAR-I;MIR146A;MIR766;MIR3622B;MIR100;MIR124A-3;ATP7;MIR375;MIR708;MIR505;MIR296;CTR1B;MIR4467
Overlap	2	2