Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
disc	clinvar	9.95e-03	7.85e-03	4.46e-09	3.18e-07
clinvar	disc	6.27e-05	9.01e-05	2.80e-11	2.54e-17



Evaluating how well disc genes are linked to clinvar genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc	clinvar	0.83	4.34	5.75	3.08	4.94
clinvar	disc	0.73	-0.26	4.78	1.14	9.90

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc	clinvar	0.01	3.42	8.67	8.21	8.61
clinvar	disc	0.02	2.82	7.54	5.38	11.47

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
disc	158	157	BRD2
clinvar	21	21