Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	GS	4.24e-01	4.41e-01	1.14e-01	9.63e-03
GS Exclusive	gene_list	1.34e-03	3.53e-01	1.09e-04	3.84e-01
gene_list Exclusive	GS Exclusive	5.99e-01	5.67e-01	3.47e-01	6.04e-03
GS Exclusive	gene_list Exclusive	1.03e-03	4.76e-01	2.16e-04	1.97e-01
gene_list Exclusive	Overlap	2.84e-01	3.31e-01	3.02e-01	8.72e-01
GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	6.17e-02	1.74e-01	4.47e-11	1.68e-01



Evaluating how well gene_list genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.64	-0.45	-0.13	-0.56	2.20
GS Exclusive	gene_list	0.49	-0.56	-0.87	-0.31	-0.38
gene_list Exclusive	GS Exclusive	0.65	-0.14	0.21	-0.28	2.33
GS Exclusive	gene_list Exclusive	0.49	-0.88	-0.76	-0.67	-0.79
gene_list Exclusive	Overlap	0.54	-1.16	-1.68	-1.39	0.28
GS Exclusive	Overlap	1.00	2.23	2.45	2.28	2.17
Overlap	Exclusives	0.52	0.41	1.06	0.19	0.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.00	-0.76	-0.80	-0.78	-0.10
GS Exclusive	gene_list	0.01	0.62	0.04	0.16	-0.19
gene_list Exclusive	GS Exclusive	0.00	-0.58	-0.61	-0.49	0.60
GS Exclusive	gene_list Exclusive	0.01	-0.49	-0.63	-0.67	-0.68
gene_list Exclusive	Overlap	0.00	-0.56	-1.73	-0.56	-0.21
GS Exclusive	Overlap	0.02	74.52	41.92	65.09	36.93
Overlap	Exclusives	0.01	4.07	3.41	1.79	2.97

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	202	202	
GS Exclusive	18	18	
Overlap	2	2