Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	GS	3.98e-01	4.41e-01	6.83e-06	2.20e-05
GS Exclusive	gene_list	1.24e-02	3.10e-01	3.66e-05	4.67e-19
gene_list Exclusive	GS Exclusive	3.07e-01	4.99e-01	3.90e-05	6.29e-05
GS Exclusive	gene_list Exclusive	6.42e-03	2.66e-01	7.08e-06	3.07e-19
gene_list Exclusive	Overlap	2.06e-01	2.06e-01	1.33e-01	3.67e-01
GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	2.04e-01	4.12e-01	1.49e-34	4.89e-20



Evaluating how well gene_list genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.78	1.00	1.24	1.58	4.04
GS Exclusive	gene_list	0.67	1.24	1.88	1.36	9.01
gene_list Exclusive	GS Exclusive	0.78	1.33	1.66	1.47	4.10
GS Exclusive	gene_list Exclusive	0.67	1.04	2.16	1.50	8.80
gene_list Exclusive	Overlap	0.77	-1.33	-1.24	0.10	0.93
GS Exclusive	Overlap	1.00	1.60	1.89	2.57	2.14
Overlap	Exclusives	0.67	0.46	1.61	1.10	10.25

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.00	1.18	2.32	2.42	2.46
GS Exclusive	gene_list	0.02	1.25	2.16	2.76	7.92
gene_list Exclusive	GS Exclusive	0.00	1.43	3.22	1.73	4.97
GS Exclusive	gene_list Exclusive	0.02	0.87	1.70	2.17	7.70
gene_list Exclusive	Overlap	0.00	-0.89	-0.54	-0.32	-0.11
GS Exclusive	Overlap	0.02	99.71	47.13	88.69	137.12
Overlap	Exclusives	0.03	1.54	5.41	2.58	13.59

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	263	263	
GS Exclusive	19	19	
Overlap	1	1