Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPIMUTESTR Exclusive	GoldStandard	5.41e-02	3.20e-03	1.69e-13	4.53e-51
GoldStandard Exclusive	EPIMUTESTR	9.21e-14	5.66e-07	2.48e-60	2.02e-35
EPIMUTESTR Exclusive	GoldStandard Exclusive	1.73e-04	5.62e-02	3.49e-04	2.11e-19
GoldStandard Exclusive	EPIMUTESTR Exclusive	2.00e-06	1.21e-01	1.40e-10	9.21e-06
EPIMUTESTR Exclusive	Overlap	9.47e-04	2.66e-06	1.06e-15	4.77e-43
GoldStandard Exclusive	Overlap	8.72e-29	1.68e-20	2.74e-86	3.90e-74
Overlap	Exclusives	3.13e-31	1.59e-23	1.48e-149	4.46e-72



Evaluating how well EPIMUTESTR genes are linked to GoldStandard genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPIMUTESTR Exclusive	GoldStandard	0.74	-0.45	4.76	1.27	17.85
GoldStandard Exclusive	EPIMUTESTR	0.71	3.43	5.74	4.05	15.72
EPIMUTESTR Exclusive	GoldStandard Exclusive	0.68	-2.08	-0.00	-0.14	8.99
GoldStandard Exclusive	EPIMUTESTR Exclusive	0.57	-0.73	-1.60	0.10	3.66
EPIMUTESTR Exclusive	Overlap	0.83	2.64	6.66	4.27	15.28
GoldStandard Exclusive	Overlap	0.93	8.70	13.32	8.04	20.02
Overlap	Exclusives	0.77	11.20	15.91	9.14	21.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPIMUTESTR Exclusive	GoldStandard	0.06	-2.19	4.55	0.16	32.44
GoldStandard Exclusive	EPIMUTESTR	0.13	11.44	45.37	18.59	115.10
EPIMUTESTR Exclusive	GoldStandard Exclusive	0.02	-2.36	-2.46	-0.96	7.86
GoldStandard Exclusive	EPIMUTESTR Exclusive	0.02	-1.07	-2.16	-0.32	2.25
EPIMUTESTR Exclusive	Overlap	0.04	-1.13	11.07	2.09	43.78
GoldStandard Exclusive	Overlap	0.25	13.78	80.26	37.19	359.74
Overlap	Exclusives	0.14	29.31	53.44	34.88	102.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPIMUTESTR Exclusive	280	276	SIGLEC5;OR4N4;FPGT.TNNI3K.TNNI3K.FPGT.TNNI3K;HLA.A
GoldStandard Exclusive	255	254	MALAT1
Overlap	169	169