Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI Exclusive	GS	1.92e-02	1.36e-04	2.61e-22	1.86e-57
GS Exclusive	EPI	6.18e-17	9.28e-09	2.01e-63	4.97e-35
EPI Exclusive	GS Exclusive	3.85e-03	1.66e-01	4.88e-07	2.82e-20
GS Exclusive	EPI Exclusive	2.90e-08	7.35e-02	1.66e-17	6.36e-08
EPI Exclusive	Overlap	8.22e-04	3.09e-06	1.20e-15	4.48e-45
GS Exclusive	Overlap	2.73e-38	2.54e-28	3.49e-94	1.95e-76
Overlap	Exclusives	1.19e-22	9.69e-14	1.70e-98	4.20e-44



Evaluating how well EPI genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI Exclusive	GS	0.81	0.02	5.76	2.18	18.36
GS Exclusive	EPI	0.70	2.88	4.68	4.11	14.74
EPI Exclusive	GS Exclusive	0.75	-2.76	1.22	0.40	11.28
GS Exclusive	EPI Exclusive	0.58	-0.60	-0.81	0.73	5.44
EPI Exclusive	Overlap	0.85	2.69	6.72	3.46	14.32
GS Exclusive	Overlap	0.94	7.73	12.62	6.21	17.80
Overlap	Exclusives	0.74	8.15	10.70	7.20	17.86

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI Exclusive	GS	0.05	-2.25	5.90	0.78	42.32
GS Exclusive	EPI	0.16	15.12	53.07	31.99	133.45
EPI Exclusive	GS Exclusive	0.02	-2.68	-1.77	-0.51	10.15
GS Exclusive	EPI Exclusive	0.02	-0.54	-1.87	0.53	4.21
EPI Exclusive	Overlap	0.04	-1.90	13.10	1.20	55.19
GS Exclusive	Overlap	0.36	17.17	137.30	64.37	618.50
Overlap	Exclusives	0.13	29.89	44.98	39.08	119.95

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI Exclusive	304	300	HLA.A;FPGT.TNNI3K.TNNI3K.FPGT.TNNI3K;SIGLEC5;OR4N4
GS Exclusive	131	131	
Overlap	145	145