Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI Exclusive	GS	1.87e-03	1.55e-02	1.27e-25	4.13e-57
GS Exclusive	EPI	6.11e-14	9.21e-06	1.55e-55	8.81e-48
EPI Exclusive	GS Exclusive	1.55e-04	1.88e-03	3.99e-13	4.85e-33
GS Exclusive	EPI Exclusive	9.95e-03	7.46e-01	7.50e-11	8.25e-08
EPI Exclusive	Overlap	2.85e-07	3.91e-06	1.93e-21	3.25e-40
GS Exclusive	Overlap	1.96e-23	4.29e-12	1.22e-64	2.39e-70
Overlap	Exclusives	6.02e-52	3.03e-64	0.00e+00	1.16e-197



Evaluating how well EPI genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI Exclusive	GS	0.64	0.77	3.41	1.94	18.86
GS Exclusive	EPI	0.74	8.60	7.37	8.39	18.47
EPI Exclusive	GS Exclusive	0.61	-0.16	-0.23	1.06	15.08
GS Exclusive	EPI Exclusive	0.60	1.01	0.37	0.93	5.06
EPI Exclusive	Overlap	0.79	3.70	7.91	4.82	16.61
GS Exclusive	Overlap	0.87	13.19	10.94	10.01	20.26
Overlap	Exclusives	0.77	15.27	25.62	12.12	38.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI Exclusive	GS	0.11	-0.51	3.03	1.62	23.60
GS Exclusive	EPI	0.15	23.73	38.63	28.55	123.48
EPI Exclusive	GS Exclusive	0.07	-1.59	-3.21	0.17	12.36
GS Exclusive	EPI Exclusive	0.02	0.23	-0.73	0.18	4.03
EPI Exclusive	Overlap	0.05	1.80	18.63	7.13	53.79
GS Exclusive	Overlap	0.22	29.34	57.08	36.19	299.14
Overlap	Exclusives	0.25	21.91	62.41	33.29	137.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI Exclusive	225	221	FPGT.TNNI3K.TNNI3K.FPGT.TNNI3K;HLA.A;SIGLEC5;OR4N4
GS Exclusive	1125	1104	MIR142;SEPT15;CHD2;MUC19;PMS2P1;CTC-432M15.3;BAGE2;RFC;GBA3;IGL;IGH;RP11-474G23.1;TRB;RPA;TRA;OR4M2;HMGN2P46;PMS2L3;MALAT1;TRD;IGK
Overlap	224	224