Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hint pp Exclusive	ctd	6.68e-02	8.68e-03	5.95e-07	3.96e-12
ctd Exclusive	hint pp	2.85e-01	7.42e-02	2.58e-07	2.30e-04
hint pp Exclusive	ctd Exclusive	5.59e-02	2.07e-02	3.66e-07	1.35e-11
ctd Exclusive	hint pp Exclusive	3.94e-01	7.75e-02	5.63e-07	3.85e-04
hint pp Exclusive	Overlap	5.95e-01	5.66e-02	2.39e-02	4.00e-02
ctd Exclusive	Overlap	7.88e-02	1.33e-01	8.14e-02	1.08e-01
Overlap	Exclusives	1.48e-11	3.68e-09	2.65e-16	3.40e-23



Evaluating how well hint pp genes are linked to ctd genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hint pp Exclusive	ctd	0.75	0.94	3.04	1.89	7.81
ctd Exclusive	hint pp	0.64	2.27	2.58	2.73	4.98
hint pp Exclusive	ctd Exclusive	0.74	0.90	3.07	1.83	7.60
ctd Exclusive	hint pp Exclusive	0.64	1.96	2.56	2.45	4.37
hint pp Exclusive	Overlap	0.81	0.98	1.77	1.91	1.70
ctd Exclusive	Overlap	0.79	2.86	1.43	1.77	1.59
Overlap	Exclusives	0.75	2.36	8.76	2.88	13.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hint pp Exclusive	ctd	0.02	1.53	4.58	4.11	13.09
ctd Exclusive	hint pp	0.01	0.91	4.14	4.83	7.80
hint pp Exclusive	ctd Exclusive	0.02	1.36	5.49	4.54	17.39
ctd Exclusive	hint pp Exclusive	0.01	-0.06	3.04	3.74	4.80
hint pp Exclusive	Overlap	0.00	-0.24	0.98	0.47	-0.13
ctd Exclusive	Overlap	0.02	179.90	81.01	52.32	93.23
Overlap	Exclusives	0.03	5.05	18.22	5.02	19.78

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hint pp Exclusive	95	95	
ctd Exclusive	100	86	SNAR-I;MIR4467;MIR766;CTR1C;MIR296;MIR708;MIR124A-3;MIR3622B;CTR1B;MIR375;ATP7;MIR146A;MIR505;MIR100
Overlap	3	3