Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	GS	5.72e-01	7.81e-01	8.59e-01	2.50e-05
GS Exclusive	gene_list	2.07e-03	3.41e-01	1.63e-02	4.18e-02
gene_list Exclusive	GS Exclusive	3.38e-01	5.68e-01	6.87e-01	1.91e-04
GS Exclusive	gene_list Exclusive	2.20e-03	2.76e-01	1.33e-02	4.91e-02
gene_list Exclusive	Overlap	4.62e-02	3.37e-02	4.23e-02	2.67e-02
GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	6.17e-08	8.46e-09	2.37e-25	4.71e-11



Evaluating how well gene_list genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.67	-0.80	-0.64	-0.59	4.82
GS Exclusive	gene_list	0.54	1.44	-0.09	0.63	1.83
gene_list Exclusive	GS Exclusive	0.66	-1.07	-1.21	-0.69	4.99
GS Exclusive	gene_list Exclusive	0.53	1.38	-0.26	0.48	1.58
gene_list Exclusive	Overlap	0.92	1.55	2.34	1.58	2.10
GS Exclusive	Overlap	1.00	2.33	2.03	2.39	2.46
Overlap	Exclusives	0.65	2.03	4.89	2.13	8.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.00	-1.15	-0.65	-0.76	2.94
GS Exclusive	gene_list	0.01	2.61	0.90	0.45	1.43
gene_list Exclusive	GS Exclusive	0.00	-1.02	-0.96	-0.71	2.97
GS Exclusive	gene_list Exclusive	0.01	-0.06	-0.83	-0.43	-0.02
gene_list Exclusive	Overlap	0.00	0.32	4.64	1.13	0.48
GS Exclusive	Overlap	0.06	112.77	192.94	151.14	115.10
Overlap	Exclusives	0.03	10.92	22.47	8.69	17.62

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	150	150	
GS Exclusive	53	53	
Overlap	2	2