Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	GS	1.72e-01	6.60e-01	7.84e-02	1.65e-02
GS Exclusive	gene_list	1.74e-06	7.92e-02	4.37e-11	4.59e-01
gene_list Exclusive	GS Exclusive	1.57e-01	5.79e-01	1.46e-01	4.61e-02
GS Exclusive	gene_list Exclusive	4.09e-06	9.51e-02	7.51e-12	4.65e-01
gene_list Exclusive	Overlap	5.70e-01	2.06e-01	3.35e-01	2.40e-01
GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	2.37e-13	1.79e-01	2.96e-34	2.10e-01



Evaluating how well gene_list genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.65	-1.10	-0.51	-1.68	2.50
GS Exclusive	gene_list	0.49	-0.51	-1.11	-0.49	-0.80
gene_list Exclusive	GS Exclusive	0.64	-1.20	-0.61	-1.28	2.13
GS Exclusive	gene_list Exclusive	0.49	-0.52	-1.38	-0.27	-0.73
gene_list Exclusive	Overlap	0.83	0.49	0.98	0.72	1.17
GS Exclusive	Overlap	1.00	1.46	1.48	1.84	1.90
Overlap	Exclusives	0.51	0.46	0.43	0.23	0.93

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.00	-0.86	-0.85	-1.12	0.32
GS Exclusive	gene_list	0.03	-0.43	-0.97	-0.74	-1.36
gene_list Exclusive	GS Exclusive	0.00	-0.99	-0.97	-1.16	0.77
GS Exclusive	gene_list Exclusive	0.03	-0.46	-1.28	-0.60	-1.35
gene_list Exclusive	Overlap	0.00	-0.17	0.03	-0.07	0.02
GS Exclusive	Overlap	0.04	79.00	152.29	81.36	57.96
Overlap	Exclusives	0.04	1.07	3.30	1.01	2.55

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	600	598	MRPL23;CCDC7
GS Exclusive	19	19	
Overlap	1	1