Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	GS	2.78e-01	3.07e-01	6.21e-01	3.73e-04
GS Exclusive	gene_list	2.13e-01	5.87e-01	3.04e-04	1.21e-03
gene_list Exclusive	GS Exclusive	2.18e-01	3.56e-01	8.15e-01	7.90e-04
GS Exclusive	gene_list Exclusive	2.55e-01	5.77e-01	1.80e-05	1.67e-03
gene_list Exclusive	Overlap	1.85e-01	4.17e-01	1.85e-01	2.28e-01
GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	8.99e-08	1.60e-03	1.23e-13	9.79e-06



Evaluating how well gene_list genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.71	0.22	1.54	0.65	3.24
GS Exclusive	gene_list	0.58	0.39	-0.30	-0.11	3.03
gene_list Exclusive	GS Exclusive	0.70	0.09	1.20	0.52	3.37
GS Exclusive	gene_list Exclusive	0.58	0.33	-0.67	0.02	2.90
gene_list Exclusive	Overlap	0.89	0.97	1.05	0.99	1.35
GS Exclusive	Overlap	1.00	1.49	1.69	2.17	1.65
Overlap	Exclusives	0.65	1.07	3.47	1.30	6.61

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.00	-0.39	0.33	-0.07	1.06
GS Exclusive	gene_list	0.01	0.40	0.27	-0.11	1.28
gene_list Exclusive	GS Exclusive	0.00	-0.56	0.27	-0.10	1.03
GS Exclusive	gene_list Exclusive	0.01	0.07	-0.76	-0.21	1.12
gene_list Exclusive	Overlap	0.00	-0.03	0.33	-0.13	0.06
GS Exclusive	Overlap	0.04	22.73	179.11	164.50	94.71
Overlap	Exclusives	0.02	2.94	13.13	2.00	18.43

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	126	125	MRPL23
GS Exclusive	19	19	
Overlap	1	1