Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	GS	8.20e-01	9.41e-01	2.76e-01	1.46e-07
GS Exclusive	gene_list	5.63e-10	6.98e-01	1.87e-05	1.87e-02
gene_list Exclusive	GS Exclusive	7.65e-01	9.60e-01	4.65e-01	4.36e-06
GS Exclusive	gene_list Exclusive	7.91e-10	3.20e-01	5.01e-05	2.94e-02
gene_list Exclusive	Overlap	8.97e-01	8.77e-01	2.57e-01	3.94e-03
GS Exclusive	Overlap	1.69e-04	2.04e-04	1.69e-04	2.45e-04
Overlap	Exclusives	1.56e-04	4.08e-03	5.25e-48	2.37e-06



Evaluating how well gene_list genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.75	-0.83	0.04	0.19	6.58
GS Exclusive	gene_list	0.53	0.90	-0.16	0.47	2.27
gene_list Exclusive	GS Exclusive	0.74	-0.87	-0.07	0.01	6.29
GS Exclusive	gene_list Exclusive	0.53	0.86	-0.54	0.29	2.13
gene_list Exclusive	Overlap	0.87	0.58	0.82	0.93	2.88
GS Exclusive	Overlap	1.00	2.32	3.05	2.79	3.50
Overlap	Exclusives	0.57	0.83	2.07	0.97	6.17

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.01	-1.11	-3.24	-0.05	3.75
GS Exclusive	gene_list	0.03	1.90	0.60	1.40	2.51
gene_list Exclusive	GS Exclusive	0.01	-1.08	-3.32	-0.03	13.83
GS Exclusive	gene_list Exclusive	0.03	1.01	-1.00	0.22	1.03
gene_list Exclusive	Overlap	0.00	-0.13	-0.53	0.19	0.34
GS Exclusive	Overlap	0.09	62.12	410.10	236.46	185.77
Overlap	Exclusives	0.05	6.76	13.64	6.64	17.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	497	494	NLGN4Y;PPIAL4C;GIMAP1-GIMAP5
GS Exclusive	51	51	
Overlap	4	4