Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	GS	6.09e-01	9.27e-02	1.59e-14	5.88e-14
GS Exclusive	gene_list	2.50e-10	1.70e-01	2.64e-18	1.47e-14
gene_list Exclusive	GS Exclusive	5.84e-01	7.74e-02	3.73e-13	1.39e-12
GS Exclusive	gene_list Exclusive	1.74e-10	2.32e-01	6.87e-18	2.25e-14
gene_list Exclusive	Overlap	8.50e-01	8.14e-01	9.25e-02	7.39e-02
GS Exclusive	Overlap	1.38e-03	1.38e-03	1.38e-03	1.38e-03
Overlap	Exclusives	8.44e-05	1.70e-05	9.92e-51	1.89e-34



Evaluating how well gene_list genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.84	1.39	3.86	2.92	8.32
GS Exclusive	gene_list	0.67	-1.46	1.44	2.08	10.67
gene_list Exclusive	GS Exclusive	0.83	1.25	3.70	2.62	9.07
GS Exclusive	gene_list Exclusive	0.66	-1.58	1.40	1.81	10.54
gene_list Exclusive	Overlap	0.84	0.37	0.42	0.74	1.96
GS Exclusive	Overlap	1.00	2.83	2.48	2.78	3.15
Overlap	Exclusives	0.73	2.08	4.88	1.88	14.78

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.02	0.18	-5.37	3.19	29.90
GS Exclusive	gene_list	0.03	0.21	2.77	5.93	14.44
gene_list Exclusive	GS Exclusive	0.02	-0.07	-6.08	2.76	5.78
GS Exclusive	gene_list Exclusive	0.03	-1.17	1.33	4.00	12.09
gene_list Exclusive	Overlap	0.00	1.03	0.67	1.46	0.23
GS Exclusive	Overlap	0.08	147.06	327.86	240.85	383.41
Overlap	Exclusives	0.06	14.01	28.04	11.40	53.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	276	275	PRODH
GS Exclusive	52	52	
Overlap	3	3