Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	GS	1.28e-05	3.58e-08	1.94e-14	4.32e-19
GS Exclusive	gene_list	2.76e-18	1.69e-07	8.86e-37	1.49e-18
gene_list Exclusive	GS Exclusive	3.32e-05	2.38e-07	8.70e-14	8.33e-19
GS Exclusive	gene_list Exclusive	2.06e-17	1.73e-07	1.37e-36	9.47e-19
gene_list Exclusive	Overlap	5.40e-01	3.51e-01	5.40e-01	1.14e-01
GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	1.29e-22	1.21e-11	8.12e-66	1.66e-34



Evaluating how well gene_list genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.85	2.75	6.49	3.65	9.40
GS Exclusive	gene_list	0.63	3.26	6.70	2.68	13.11
gene_list Exclusive	GS Exclusive	0.85	2.87	5.73	3.13	9.34
GS Exclusive	gene_list Exclusive	0.63	3.37	6.64	2.44	13.03
gene_list Exclusive	Overlap	0.83	-0.46	2.04	0.58	1.65
GS Exclusive	Overlap	1.00	2.37	2.46	2.32	2.40
Overlap	Exclusives	0.65	1.53	6.08	1.19	12.92

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.01	-1.09	11.49	0.47	4.91
GS Exclusive	gene_list	0.06	6.13	13.68	5.51	22.84
gene_list Exclusive	GS Exclusive	0.01	-1.43	8.18	0.43	20.43
GS Exclusive	gene_list Exclusive	0.06	4.96	12.25	4.50	19.91
gene_list Exclusive	Overlap	0.00	0.27	4.60	0.92	0.23
GS Exclusive	Overlap	0.52	84.32	1326.96	2266.04	977.06
Overlap	Exclusives	0.07	4.07	12.63	2.32	24.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	681	679	FOLH1B;MRPL23
GS Exclusive	53	53	
Overlap	2	2