Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	GS	5.66e-01	3.82e-03	4.01e-03	1.01e-10
GS Exclusive	gene_list	3.97e-03	3.69e-01	1.30e-03	3.89e-02
gene_list Exclusive	GS Exclusive	7.93e-01	7.15e-03	1.00e-02	2.66e-10
GS Exclusive	gene_list Exclusive	2.21e-03	3.73e-01	5.57e-03	5.49e-02
gene_list Exclusive	Overlap	1.05e-01	4.35e-01	1.95e-01	2.06e-01
GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	5.10e-10	7.70e-09	5.91e-26	5.13e-14



Evaluating how well gene_list genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.75	0.69	3.33	1.37	6.92
GS Exclusive	gene_list	0.58	0.34	-0.26	0.45	2.57
gene_list Exclusive	GS Exclusive	0.75	0.56	2.91	1.21	6.30
GS Exclusive	gene_list Exclusive	0.57	0.25	-0.35	-0.09	2.76
gene_list Exclusive	Overlap	0.89	1.46	1.12	1.05	1.32
GS Exclusive	Overlap	1.00	2.18	1.63	1.45	1.99
Overlap	Exclusives	0.70	1.29	5.41	2.10	9.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.01	-0.73	2.59	0.54	4.86
GS Exclusive	gene_list	0.01	0.95	1.54	0.70	3.25
gene_list Exclusive	GS Exclusive	0.01	-0.73	2.16	0.34	6.32
GS Exclusive	gene_list Exclusive	0.01	0.23	0.34	-0.05	1.35
gene_list Exclusive	Overlap	0.00	1.48	0.46	-0.01	0.10
GS Exclusive	Overlap	0.05	223.17	186.30	96.24	130.64
Overlap	Exclusives	0.03	3.51	19.83	3.91	15.28

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	126	125	MRPL23
GS Exclusive	54	54	
Overlap	1	1