Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	GS	2.87e-02	8.80e-02	1.02e-01	1.96e-02
GS Exclusive	gene_list	3.53e-01	4.39e-01	9.30e-03	5.65e-02
gene_list Exclusive	GS Exclusive	7.43e-03	6.81e-02	5.44e-02	2.59e-02
GS Exclusive	gene_list Exclusive	3.23e-01	5.19e-01	4.43e-03	7.86e-02
gene_list Exclusive	Overlap	1.95e-01	1.41e-01	1.95e-01	1.95e-01
GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	2.02e-08	1.51e-06	3.80e-13	4.07e-09



Evaluating how well gene_list genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.60	-0.71	-0.41	-0.55	1.60
GS Exclusive	gene_list	0.59	0.78	0.81	0.29	2.10
gene_list Exclusive	GS Exclusive	0.59	-1.08	-0.70	-0.69	1.22
GS Exclusive	gene_list Exclusive	0.58	0.87	0.49	0.32	1.60
gene_list Exclusive	Overlap	0.91	1.20	2.09	1.13	1.48
GS Exclusive	Overlap	1.00	1.40	1.73	2.01	1.60
Overlap	Exclusives	0.75	2.05	5.98	2.52	7.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.00	-0.18	-0.07	-0.13	0.58
GS Exclusive	gene_list	0.00	0.77	1.66	1.18	2.62
gene_list Exclusive	GS Exclusive	0.00	-0.49	-0.19	-0.24	0.24
GS Exclusive	gene_list Exclusive	0.00	-0.07	-0.26	-0.21	-0.06
gene_list Exclusive	Overlap	0.00	0.17	1.37	0.00	0.20
GS Exclusive	Overlap	0.04	69.31	240.11	74.08	115.27
Overlap	Exclusives	0.02	9.58	21.32	9.74	35.67

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	46	46	
GS Exclusive	19	19	
Overlap	1	1