Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	GS	4.13e-01	3.72e-01	1.98e-01	2.66e-10
GS Exclusive	gene_list	8.12e-37	1.63e-03	2.27e-10	1.80e-01
gene_list Exclusive	GS Exclusive	3.53e-01	3.99e-01	1.11e-01	7.79e-10
GS Exclusive	gene_list Exclusive	2.49e-37	1.58e-03	7.02e-10	2.15e-01
gene_list Exclusive	Overlap	2.43e-02	1.91e-01	6.52e-02	8.35e-02
GS Exclusive	Overlap	1.15e-02	1.28e-02	1.15e-02	1.15e-02
Overlap	Exclusives	2.42e-18	5.99e-11	5.04e-54	1.54e-10



Evaluating how well gene_list genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.76	0.43	1.72	-0.28	6.79
GS Exclusive	gene_list	0.49	-0.65	-3.32	-0.35	-1.35
gene_list Exclusive	GS Exclusive	0.76	-0.08	1.50	-0.62	6.48
GS Exclusive	gene_list Exclusive	0.49	-0.60	-3.05	-0.30	-1.20
gene_list Exclusive	Overlap	0.85	2.84	1.40	2.53	1.60
GS Exclusive	Overlap	1.00	3.09	2.33	2.60	2.41
Overlap	Exclusives	0.55	1.46	5.98	1.76	5.84

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.01	-1.62	-0.47	-1.90	5.45
GS Exclusive	gene_list	0.06	0.60	-1.03	0.07	-1.14
gene_list Exclusive	GS Exclusive	0.01	-2.02	-0.42	-1.85	7.48
GS Exclusive	gene_list Exclusive	0.06	0.31	-1.53	-0.05	-1.32
gene_list Exclusive	Overlap	0.00	6.13	-0.05	4.80	0.11
GS Exclusive	Overlap	0.03	83.56	24.48	103.41	62.18
Overlap	Exclusives	0.08	2.00	13.25	3.49	10.93

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	1112	1106	ZNF286A;ZNF816-ZNF321P;MRPL23;CCDC7;TM9SF1;ZNF709
GS Exclusive	53	53	
Overlap	2	2