Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	GS	9.07e-01	4.76e-01	5.01e-01	5.62e-03
GS Exclusive	gene_list	3.95e-02	7.43e-01	1.16e-03	1.95e-02
gene_list Exclusive	GS Exclusive	9.43e-01	2.50e-01	2.12e-01	1.37e-02
GS Exclusive	gene_list Exclusive	2.85e-02	7.65e-01	2.70e-03	3.97e-02
gene_list Exclusive	Overlap	3.83e-01	8.29e-01	8.47e-01	8.11e-01
GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	8.13e-10	9.63e-06	1.16e-14	7.54e-08



Evaluating how well gene_list genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.69	0.15	1.05	0.25	3.30
GS Exclusive	gene_list	0.55	0.28	0.04	-0.39	2.14
gene_list Exclusive	GS Exclusive	0.70	0.26	1.40	0.66	2.74
GS Exclusive	gene_list Exclusive	0.55	0.12	0.07	-0.49	1.75
gene_list Exclusive	Overlap	0.54	-0.66	-0.07	-0.34	-0.00
GS Exclusive	Overlap	1.00	1.33	1.81	1.90	1.70
Overlap	Exclusives	0.64	1.88	3.86	1.83	6.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.00	-0.36	0.00	-0.28	0.82
GS Exclusive	gene_list	0.01	1.67	0.26	0.30	1.12
gene_list Exclusive	GS Exclusive	0.00	-0.34	0.33	0.02	1.11
GS Exclusive	gene_list Exclusive	0.01	0.67	-0.02	-0.14	0.53
gene_list Exclusive	Overlap	0.00	-0.15	-0.32	-0.19	-0.23
GS Exclusive	Overlap	0.04	18.87	206.77	150.40	78.92
Overlap	Exclusives	0.02	4.98	10.30	5.85	15.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	125	125	
GS Exclusive	19	19	
Overlap	1	1