Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	GS	5.75e-01	7.29e-01	2.40e-05	2.90e-04
GS Exclusive	gene_list	4.25e-04	2.62e-01	1.84e-08	9.98e-24
gene_list Exclusive	GS Exclusive	8.03e-01	8.14e-01	3.80e-04	1.67e-03
GS Exclusive	gene_list Exclusive	9.11e-04	2.54e-01	9.74e-09	7.35e-24
gene_list Exclusive	Overlap	5.27e-01	4.05e-01	2.80e-02	5.99e-02
GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	4.89e-02	1.57e-01	2.57e-21	3.03e-18



Evaluating how well gene_list genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.76	0.93	0.96	1.08	3.90
GS Exclusive	gene_list	0.68	0.89	1.81	1.32	9.82
gene_list Exclusive	GS Exclusive	0.76	0.83	0.78	1.13	3.82
GS Exclusive	gene_list Exclusive	0.68	0.90	1.50	1.31	10.32
gene_list Exclusive	Overlap	0.78	0.53	0.32	0.46	1.51
GS Exclusive	Overlap	1.00	1.81	2.84	2.45	2.41
Overlap	Exclusives	0.68	-0.26	1.67	0.29	11.63

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.00	0.90	1.70	0.97	3.07
GS Exclusive	gene_list	0.02	1.30	2.34	3.03	9.20
gene_list Exclusive	GS Exclusive	0.00	0.95	2.14	1.77	2.93
GS Exclusive	gene_list Exclusive	0.02	0.81	1.22	2.78	9.46
gene_list Exclusive	Overlap	0.00	0.05	-0.37	-0.21	0.23
GS Exclusive	Overlap	0.04	29.68	164.39	118.08	136.27
Overlap	Exclusives	0.03	4.58	10.14	4.15	22.31

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	274	274	
GS Exclusive	18	18	
Overlap	2	2