Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
disc Exclusive	ctd	7.37e-03	7.26e-02	2.35e-16	1.88e-15
ctd Exclusive	disc	5.44e-03	1.08e-01	4.75e-10	4.21e-09
disc Exclusive	ctd Exclusive	6.10e-03	5.07e-02	2.22e-15	1.82e-14
ctd Exclusive	disc Exclusive	1.82e-02	1.97e-01	5.18e-09	8.18e-09
disc Exclusive	Overlap	5.40e-01	6.60e-01	5.27e-02	5.50e-02
ctd Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.22e-02
Overlap	Exclusives	1.10e-13	1.37e-13	4.94e-51	1.99e-38



Evaluating how well disc genes are linked to ctd genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc Exclusive	ctd	0.78	2.66	3.08	2.79	10.09
ctd Exclusive	disc	0.71	-1.64	2.62	2.02	6.92
disc Exclusive	ctd Exclusive	0.78	2.55	3.67	3.19	7.55
ctd Exclusive	disc Exclusive	0.70	-1.88	2.20	1.71	6.40
disc Exclusive	Overlap	0.91	-0.23	0.12	1.48	2.03
ctd Exclusive	Overlap	1.00	2.60	2.00	2.16	2.39
Overlap	Exclusives	0.81	3.89	9.15	3.05	13.72

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc Exclusive	ctd	0.02	2.63	4.17	6.93	31.45
ctd Exclusive	disc	0.02	2.41	12.73	11.65	25.25
disc Exclusive	ctd Exclusive	0.02	2.19	4.12	8.01	10.81
ctd Exclusive	disc Exclusive	0.01	-1.43	4.02	5.46	14.17
disc Exclusive	Overlap	0.00	0.97	0.58	6.24	7.06
ctd Exclusive	Overlap	0.16	294.69	350.20	548.83	31.77
Overlap	Exclusives	0.05	13.11	34.80	9.53	62.57

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
disc Exclusive	89	88	RNASE12
ctd Exclusive	101	87	MIR708;MIR3622B;MIR296;ATP7;MIR375;SNAR-I;MIR505;MIR766;CTR1C;MIR4467;MIR124A-3;CTR1B;MIR146A;MIR100
Overlap	2	2