Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
disc Exclusive	ctd	7.11e-03	1.03e-01	1.34e-18	5.71e-15
ctd Exclusive	disc	6.85e-06	9.85e-03	1.25e-15	2.77e-13
disc Exclusive	ctd Exclusive	5.92e-03	1.28e-01	3.04e-17	7.73e-14
ctd Exclusive	disc Exclusive	6.72e-06	3.01e-02	5.16e-15	5.14e-12
disc Exclusive	Overlap	5.40e-01	7.14e-01	1.49e-02	5.74e-02
ctd Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	4.85e-10	7.84e-13	2.53e-39	1.85e-39



Evaluating how well disc genes are linked to ctd genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc Exclusive	ctd	0.79	3.28	3.65	3.09	9.61
ctd Exclusive	disc	0.70	-5.49	2.23	1.36	9.47
disc Exclusive	ctd Exclusive	0.79	3.22	3.99	3.11	9.76
ctd Exclusive	disc Exclusive	0.69	-4.94	2.11	1.18	9.27
disc Exclusive	Overlap	0.90	2.00	0.94	1.64	1.98
ctd Exclusive	Overlap	1.00	2.74	2.25	2.37	2.48
Overlap	Exclusives	0.77	2.46	8.07	2.47	15.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc Exclusive	ctd	0.03	3.36	3.27	8.16	16.86
ctd Exclusive	disc	0.03	-0.35	9.63	10.99	33.43
disc Exclusive	ctd Exclusive	0.03	3.30	3.79	8.88	28.30
ctd Exclusive	disc Exclusive	0.02	-1.79	5.72	7.26	15.10
disc Exclusive	Overlap	0.00	0.36	0.81	2.09	0.68
ctd Exclusive	Overlap	0.13	397.63	768.70	594.45	382.90
Overlap	Exclusives	0.05	8.35	22.23	4.70	36.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
disc Exclusive	153	152	BRD2
ctd Exclusive	101	87	MIR505;MIR100;CTR1C;MIR296;SNAR-I;ATP7;MIR708;MIR146A;MIR4467;MIR766;MIR3622B;MIR375;CTR1B;MIR124A-3
Overlap	2	2