Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wavelet-Common Exclusive	BRCA-All-GS	2.00e-04	3.48e-02	5.72e-24	7.84e-19
BRCA-All-GS Exclusive	Wavelet-Common	4.82e-04	8.09e-02	2.41e-16	6.17e-12
Wavelet-Common Exclusive	BRCA-All-GS Exclusive	9.31e-04	6.27e-02	2.92e-21	1.46e-16
BRCA-All-GS Exclusive	Wavelet-Common Exclusive	6.07e-03	2.81e-01	7.35e-14	3.14e-09
Wavelet-Common Exclusive	Overlap	1.26e-02	3.60e-02	2.37e-04	5.08e-06
BRCA-All-GS Exclusive	Overlap	1.35e-07	4.24e-07	5.33e-09	9.80e-09
Overlap	Exclusives	5.94e-25	1.21e-14	4.93e-60	1.22e-40



Evaluating how well Wavelet-Common genes are linked to BRCA-All-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wavelet-Common Exclusive	BRCA-All-GS	0.68	-0.17	1.47	2.22	10.46
BRCA-All-GS Exclusive	Wavelet-Common	0.70	-1.79	1.22	2.00	7.91
Wavelet-Common Exclusive	BRCA-All-GS Exclusive	0.67	-0.52	1.19	2.03	8.48
BRCA-All-GS Exclusive	Wavelet-Common Exclusive	0.68	-1.97	0.94	1.39	7.53
Wavelet-Common Exclusive	Overlap	0.94	1.62	2.32	2.57	5.42
BRCA-All-GS Exclusive	Overlap	1.00	3.20	3.45	2.93	5.76
Overlap	Exclusives	0.74	4.67	9.13	3.45	15.41

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wavelet-Common Exclusive	BRCA-All-GS	0.05	-0.11	8.21	7.39	29.68
BRCA-All-GS Exclusive	Wavelet-Common	0.04	8.84	19.59	19.38	55.99
Wavelet-Common Exclusive	BRCA-All-GS Exclusive	0.04	-0.22	7.26	6.79	27.67
BRCA-All-GS Exclusive	Wavelet-Common Exclusive	0.02	-0.07	2.62	3.31	16.08
Wavelet-Common Exclusive	Overlap	0.01	-0.29	1.48	5.36	35.83
BRCA-All-GS Exclusive	Overlap	0.31	13.29	274.16	103.18	160.57
Overlap	Exclusives	0.12	18.37	58.95	31.66	120.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wavelet-Common Exclusive	126	125	7-Mar
BRCA-All-GS Exclusive	253	253	
Overlap	9	9