Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
STRING-AC4 Exclusive	BRCA-All-GS	9.13e-02	5.90e-02	3.19e-01	6.87e-17
BRCA-All-GS Exclusive	STRING-AC4	7.95e-05	1.05e-01	5.10e-12	1.03e-03
STRING-AC4 Exclusive	BRCA-All-GS Exclusive	3.02e-01	9.73e-02	3.39e-01	1.41e-15
BRCA-All-GS Exclusive	STRING-AC4 Exclusive	1.63e-04	7.37e-02	1.86e-11	1.27e-03
STRING-AC4 Exclusive	Overlap	3.11e-01	1.62e-01	4.47e-01	1.64e-03
BRCA-All-GS Exclusive	Overlap	1.85e-06	2.91e-05	3.36e-07	7.83e-07
Overlap	Exclusives	6.41e-09	1.75e-07	3.09e-49	6.81e-14



Evaluating how well STRING-AC4 genes are linked to BRCA-All-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
STRING-AC4 Exclusive	BRCA-All-GS	0.68	1.87	2.66	0.68	10.07
BRCA-All-GS Exclusive	STRING-AC4	0.52	1.67	1.36	2.52	1.69
STRING-AC4 Exclusive	BRCA-All-GS Exclusive	0.67	1.54	2.56	0.49	9.37
BRCA-All-GS Exclusive	STRING-AC4 Exclusive	0.51	1.79	1.14	1.98	0.94
STRING-AC4 Exclusive	Overlap	0.85	1.95	2.14	1.78	3.88
BRCA-All-GS Exclusive	Overlap	0.94	2.70	2.37	2.79	4.57
Overlap	Exclusives	0.60	1.18	6.71	2.50	10.48

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
STRING-AC4 Exclusive	BRCA-All-GS	0.03	-1.81	-0.47	-1.59	14.82
BRCA-All-GS Exclusive	STRING-AC4	0.04	15.61	13.00	10.98	9.42
STRING-AC4 Exclusive	BRCA-All-GS Exclusive	0.03	-2.13	-0.55	-1.61	10.52
BRCA-All-GS Exclusive	STRING-AC4 Exclusive	0.03	3.81	1.44	1.92	0.01
STRING-AC4 Exclusive	Overlap	0.00	0.23	-0.43	0.09	3.85
BRCA-All-GS Exclusive	Overlap	0.38	99.35	159.58	238.06	810.38
Overlap	Exclusives	0.07	5.51	19.57	8.75	27.90

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
STRING-AC4 Exclusive	525	517	2021-09-14 00:00:00;PPAN-P2RY11;2021-09-06 00:00:00;2021-09-04 00:00:00;2021-09-10 00:00:00;2021-09-03 00:00:00;ZNF816-ZNF321P;2021-09-07 00:00:00
BRCA-All-GS Exclusive	253	253	
Overlap	9	9