Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Common2MethodGenes Exclusive	Somatic	2.72e-02	6.37e-01	1.23e-01	3.48e-10
Somatic Exclusive	Common2MethodGenes	1.65e-02	3.06e-01	1.74e-04	2.77e-01
Common2MethodGenes Exclusive	Somatic Exclusive	2.94e-02	5.21e-01	2.17e-01	4.84e-10
Somatic Exclusive	Common2MethodGenes Exclusive	1.07e-02	3.27e-01	2.98e-04	3.52e-01
Common2MethodGenes Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.22e-02
Somatic Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.22e-02
Overlap	Exclusives	2.76e-14	7.95e-12	1.51e-20	1.53e-15



Evaluating how well Common2MethodGenes genes are linked to Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Common2MethodGenes Exclusive	Somatic	0.79	-1.06	0.23	0.35	6.47
Somatic Exclusive	Common2MethodGenes	0.55	-1.14	-1.24	-0.61	1.94
Common2MethodGenes Exclusive	Somatic Exclusive	0.78	-1.34	0.03	0.11	6.58
Somatic Exclusive	Common2MethodGenes Exclusive	0.54	-1.30	-1.48	-0.58	1.55
Common2MethodGenes Exclusive	Overlap	1.00	1.70	2.55	1.68	2.35
Somatic Exclusive	Overlap	0.99	1.20	2.56	1.53	2.35
Overlap	Exclusives	0.70	1.39	3.21	1.73	8.38

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Common2MethodGenes Exclusive	Somatic	0.01	-0.82	1.60	0.32	9.27
Somatic Exclusive	Common2MethodGenes	0.01	-0.53	0.01	0.53	2.52
Common2MethodGenes Exclusive	Somatic Exclusive	0.01	-1.21	-0.23	-0.36	1.06
Somatic Exclusive	Common2MethodGenes Exclusive	0.00	-0.63	-0.83	-0.10	1.11
Common2MethodGenes Exclusive	Overlap	0.02	29.02	130.64	32.79	8.75
Somatic Exclusive	Overlap	0.01	1.54	40.13	14.17	8.01
Overlap	Exclusives	0.03	39.90	34.47	11.36	46.27

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Common2MethodGenes Exclusive	81	80	
Somatic Exclusive	38	38	
Overlap	2	2