Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Common2MethodGenes-q0-01 Exclusive	Somatic	9.73e-03	7.80e-01	8.07e-02	3.80e-09
Somatic Exclusive	Common2MethodGenes-q0-01	8.08e-02	6.78e-01	5.57e-04	7.91e-02
Common2MethodGenes-q0-01 Exclusive	Somatic Exclusive	2.55e-03	6.84e-01	7.78e-02	1.70e-08
Somatic Exclusive	Common2MethodGenes-q0-01 Exclusive	4.80e-02	6.61e-01	2.39e-03	1.21e-01
Common2MethodGenes-q0-01 Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.22e-02
Somatic Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.22e-02
Overlap	Exclusives	1.09e-15	6.51e-12	3.93e-21	2.68e-18



Evaluating how well Common2MethodGenes-q0-01 genes are linked to Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Common2MethodGenes-q0-01 Exclusive	Somatic	0.79	-0.94	0.82	0.80	6.07
Somatic Exclusive	Common2MethodGenes-q0-01	0.60	-0.70	-0.95	0.06	2.32
Common2MethodGenes-q0-01 Exclusive	Somatic Exclusive	0.78	-1.34	0.62	0.74	5.37
Somatic Exclusive	Common2MethodGenes-q0-01 Exclusive	0.59	-0.92	-0.95	-0.17	2.25
Common2MethodGenes-q0-01 Exclusive	Overlap	1.00	1.61	2.07	1.75	2.34
Somatic Exclusive	Overlap	0.99	1.13	2.43	1.88	2.38
Overlap	Exclusives	0.77	1.37	4.46	1.94	7.79

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Common2MethodGenes-q0-01 Exclusive	Somatic	0.01	-0.94	1.66	0.92	7.00
Somatic Exclusive	Common2MethodGenes-q0-01	0.00	-0.40	0.48	1.38	3.34
Common2MethodGenes-q0-01 Exclusive	Somatic Exclusive	0.00	-1.09	0.12	0.18	4.48
Somatic Exclusive	Common2MethodGenes-q0-01 Exclusive	0.00	-0.44	-0.80	0.33	0.13
Common2MethodGenes-q0-01 Exclusive	Overlap	0.02	20.45	85.29	44.94	23.48
Somatic Exclusive	Overlap	0.01	0.44	39.82	11.41	26.64
Overlap	Exclusives	0.03	23.86	31.22	8.40	44.61

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Common2MethodGenes-q0-01 Exclusive	51	50	
Somatic Exclusive	38	38	
Overlap	2	2