Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Common2MethodGenes-q0-01 Exclusive	GWAS	8.56e-02	8.81e-01	4.85e-02	9.14e-05
GWAS Exclusive	Common2MethodGenes-q0-01	6.85e-01	2.41e-01	1.74e-03	6.68e-04
Common2MethodGenes-q0-01 Exclusive	GWAS Exclusive	1.14e-01	9.24e-01	3.85e-02	7.72e-05
GWAS Exclusive	Common2MethodGenes-q0-01 Exclusive	8.06e-01	2.30e-01	1.33e-03	8.45e-04
Common2MethodGenes-q0-01 Exclusive	Overlap	7.88e-02	7.88e-02	7.88e-02	8.68e-02
GWAS Exclusive	Overlap	7.88e-02	1.88e-01	7.88e-02	8.96e-02
Overlap	Exclusives	8.09e-03	5.43e-04	5.42e-35	8.62e-15



Evaluating how well Common2MethodGenes-q0-01 genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Common2MethodGenes-q0-01 Exclusive	GWAS	0.62	0.05	0.62	0.87	5.50
GWAS Exclusive	Common2MethodGenes-q0-01	0.66	0.61	1.40	0.91	4.29
Common2MethodGenes-q0-01 Exclusive	GWAS Exclusive	0.61	0.14	0.60	0.89	5.04
GWAS Exclusive	Common2MethodGenes-q0-01 Exclusive	0.65	0.61	1.25	0.86	3.77
Common2MethodGenes-q0-01 Exclusive	Overlap	0.76	0.39	0.35	0.41	1.99
GWAS Exclusive	Overlap	0.77	-0.86	-0.43	0.06	1.62
Overlap	Exclusives	0.68	2.39	4.67	2.62	8.69

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Common2MethodGenes-q0-01 Exclusive	GWAS	0.01	0.03	2.19	2.16	6.86
GWAS Exclusive	Common2MethodGenes-q0-01	0.01	2.08	4.56	4.57	7.34
Common2MethodGenes-q0-01 Exclusive	GWAS Exclusive	0.01	-0.25	0.76	1.36	2.91
GWAS Exclusive	Common2MethodGenes-q0-01 Exclusive	0.01	0.26	2.33	2.09	4.88
Common2MethodGenes-q0-01 Exclusive	Overlap	0.01	6.03	45.31	33.41	10.39
GWAS Exclusive	Overlap	0.01	6.97	1.02	25.64	25.43
Overlap	Exclusives	0.03	4.77	11.86	6.20	11.49

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Common2MethodGenes-q0-01 Exclusive	49	49	
GWAS Exclusive	165	165	
Overlap	4	3