Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Rare2MethodGenes-q0-01 Exclusive	Somatic	7.49e-01	5.54e-01	6.07e-03	4.18e-12
Somatic Exclusive	Rare2MethodGenes-q0-01	2.01e-02	9.57e-01	1.06e-04	3.41e-02
Rare2MethodGenes-q0-01 Exclusive	Somatic Exclusive	4.76e-01	5.04e-01	9.45e-03	9.82e-11
Somatic Exclusive	Rare2MethodGenes-q0-01 Exclusive	1.81e-02	9.96e-01	9.59e-05	5.03e-02
Rare2MethodGenes-q0-01 Exclusive	Overlap	1.85e-03	1.38e-03	1.38e-03	1.45e-03
Somatic Exclusive	Overlap	1.38e-03	1.38e-03	1.38e-03	1.38e-03
Overlap	Exclusives	3.30e-10	2.34e-06	3.68e-38	6.61e-12



Evaluating how well Rare2MethodGenes-q0-01 genes are linked to Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Rare2MethodGenes-q0-01 Exclusive	Somatic	0.83	-0.38	1.47	1.44	7.36
Somatic Exclusive	Rare2MethodGenes-q0-01	0.60	-0.28	0.23	0.52	3.32
Rare2MethodGenes-q0-01 Exclusive	Somatic Exclusive	0.82	-0.45	1.23	1.23	6.01
Somatic Exclusive	Rare2MethodGenes-q0-01 Exclusive	0.59	-0.02	-0.02	0.51	3.09
Rare2MethodGenes-q0-01 Exclusive	Overlap	1.00	1.32	2.48	1.46	2.91
Somatic Exclusive	Overlap	1.00	1.12	2.82	1.88	3.17
Overlap	Exclusives	0.71	2.52	3.60	1.86	8.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Rare2MethodGenes-q0-01 Exclusive	Somatic	0.01	-0.84	1.95	1.57	11.70
Somatic Exclusive	Rare2MethodGenes-q0-01	0.01	-0.58	0.61	1.75	3.91
Rare2MethodGenes-q0-01 Exclusive	Somatic Exclusive	0.01	-1.18	0.03	0.34	1.35
Somatic Exclusive	Rare2MethodGenes-q0-01 Exclusive	0.01	-0.38	-0.54	0.54	2.01
Rare2MethodGenes-q0-01 Exclusive	Overlap	0.02	0.54	34.85	7.01	45.75
Somatic Exclusive	Overlap	0.01	-0.49	39.90	13.91	55.91
Overlap	Exclusives	0.03	23.51	17.79	10.13	33.86

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Rare2MethodGenes-q0-01 Exclusive	89	86	;SSPO;C4B_2
Somatic Exclusive	37	37	
Overlap	3	3